Abstract:
Background: Diabetic nephropathy (DN) is characterized by proteinuria and is one of the
most serious long-term micro vascular complications of DM. The primary cause of end-stage
renal disease and chronic kidney illnesses, which make up the majority of the workload at
dialysis facilities globally, the earliest indicator of DN is proteinuria; hence, DN progression
is slowed down by early identification, and proteinuria prompts diabetes management.
Objective: The objective of this study is to assess determinants of diabetic nephropathy
among diabetes mellitus patients Attending follow up in comprehensive specialized,
Northeast Amhara, Ethiopia, in 2023.
Method: An institution-based unmatched case-control study was conducted among 553
diabetic patients from April 1 April 30 /2023 attending follow in comprehensive specialized
hospitals. The cases were selected consecutively and the controls were selected by the
systematic random sampling technique. Data was entered into Epi data version 4.6 and
Bivariable logistic regression analysis were entered into the multivariable logistic analysis,
variable with a p-vale <0.05 in multivariable logistic regression analysis were considered
statistically significant and Results were presented in the text, tables, and with an adjusted
odds ratio (AOR) and corresponding 95% confidence interval.
Results A total of 141 cases and 412 controls were participated in this study. The mean age
of study participants in DM was 60.78± (SD 13.69) and in control 50.26± (SD 15.27).
Comorbidity (AOR 3.28 at 95% CI: 2.08–5.167), poor glycaemic control (AOR: 2.81 at 95%
CI: 1.62–4.87), AOR 2.59 at 95% CI: 1.482–5.716 and Diastolic hypertension (AOR: 2.59 at
95% CI: 1.482–5.716) were significant factors of diabetic nephropathy that made an
association at a p-value < 0.05.
Conclusion in this study, comorbidity and poor glycaemic control and Diastolic
hypertension were determinants of diabetic nephropathy in diabetes patients
Key Words: Diabetes Mellitus, Determinants, nephropathy Ethiopia.
