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Acute and Sub-Acute Toxicity Study of Selected Medicinal Plants for the Application of Perfumery

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dc.contributor.author Amare, Ayalew
dc.contributor.author Yosef, Eshete
dc.contributor.author Minable, Gashu
dc.contributor.author Shimels, Sahile
dc.contributor.author Yihenew, Sewale
dc.contributor.author Solomon, Tadesse
dc.date.accessioned 2022-07-07T08:48:16Z
dc.date.available 2022-07-07T08:48:16Z
dc.date.issued 2021-10
dc.identifier.uri http://etd.dbu.edu.et:80/handle/123456789/971
dc.description.abstract Objective: - This study was aimed at investigating the acute and sub-acute toxicities of essential oils of Cymbopogon martini and Cymbopogon nardus in mice model. Methods: - The median lethal dose (LD50) of essential oils of Cymbopogon martini and Cymbopogon nardus was determined according to the method described by Chinedu et al, 2013. The repeated dose 28-day oral toxicity study was conducted in female mice in accordance with Organization for Economic Cooperation and Development (OECD) 407 guideline. Experimental mice were randomly allocated in five groups of 10 mice in each. Group I received the same volume of saline and considered as the control group. Group II and Group III were treated with C. martini at a dose of 500 mg/kg and 1000 mg/kg body weight respectively. Group IV and Group V were administered with C. nardus at a dose of 500 mg/kg and 1000 mg/kg body weight respectively. Acute toxicity study results and traditional claims were used for determination of doses for sub-acute toxicity study. Results: -The acute toxicity study showed that the LD50 of essential oils of C. martini and C. nardus was found to be greater than 5000 mg/kg body weight. Treatment related signs of toxicity and mortality were not observed in both sexes of mice treated with essential oils of C. martini and C. nardus at doses of 500 mg/kg and 1000 mg/kg body weight during 4 weeks follow-up. Histopathological examination of the liver and kidney of mice that received essential oil of these plants at doses of 500 mg/kg and 1000 mg /kg body weight did not reveal abnormal findings. Conclusion: - The data generated from the current study provide the safety of essential oils of Cimbopogon martini and Cimbopogon nardus for cosmetic purpose. In conclusion, Ethiopian C. martini and C. nardus essential oils may be considered as non-toxic. en_US
dc.language.iso en en_US
dc.subject - Acute toxicity, Sub-acute toxicity, Cymbopogon martini, Cymbopogon nardus en_US
dc.title Acute and Sub-Acute Toxicity Study of Selected Medicinal Plants for the Application of Perfumery en_US
dc.type Article en_US


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