Abstract:
Among the vast number of noncommunicable diseases encountered worldwide, cardiovascular
diseases accounted for about 17.8 million deaths in 2017 and ischemic heart disease (IHD)
remains the single-largest cause of death in countries across all income groups. Because
conventional medications are not without shortcomings and patients still refractory to these
medications, scientific investigation is ongoing to advance the management of IHD, and shows a
great promise for better treatment modalities, but additional research can warrant improvement
in terms of the quality of life of patients. Metabolic modulation is one promising strategy for the
treatment of IHD, because alterations in energy metabolism are involved in progression of the
disease. Therefore, the purpose of this review was to strengthen attention toward the use of
metabolic modulators and to review the current level of knowledge on cardiac energy metabolic
pathways.